Virus and immune response

Activity and Physiological Trackers To Detect And Monitor Pandemic Effects

Wearable devices are increasingly used in the USA and globally to monitor individual health. Data collected from personal sensors can improve remote patient monitoring, enhance our pandemic response, and track secondary and long-term effects of COVID-19.

Immune Vulnerability and SARS- CoV-2 Virus Variants in Older and General Populations

There is an urgent need to understand defects of immunity against SARS-CoV-2 in older adults, including its breadth across different antigens of the virus, clonal complexity, functional adequacy, durability, and the ability to guard against virus escape variants. The current pandemic presents a once-in-a-lifetime opportunity to address these needs and fill the gaps in knowledge, with the purpose to protect both adult and older populations from COVID-19.

Predicting the Duration of SARS-CoV-2

The duration of immunity to the SARS-CoV-2 virus varies widely with the specific vaccine or infection, yet the molecular bases of these differences remain a mystery. There is currently no substitute for following antibody and cellular immune responses over time to determine the duration of immunity after infection or vaccination. This is an unsatisfyingly slow solution. A predictive set of cellular and molecular properties in the early immune response would allow for greater success in vaccine development.