Activity and Physiological Trackers To Detect And Monitor Pandemic Effects Integration of high-precision laboratory data and computational modeling to inform quantitative microbial risk assessments of pathogen transmission under various conditions within indoor environments. Read more Immune Vulnerability and SARS- CoV-2 Virus Variants in Older and General Populations There is an urgent need to understand defects of immunity against SARS-CoV-2 in older adults, including its breadth across different antigens of the virus, clonal complexity, functional adequacy, durability, and the ability to guard against virus escape variants. The current pandemic presents a once-in-a-lifetime opportunity to address these needs and fill the gaps in knowledge, with the purpose to protect both adult and older populations from COVID-19. Read more Predicting the Duration of SARS-CoV-2 The duration of immunity to the SARS-CoV-2 virus varies widely with the specific vaccine or infection, yet the molecular bases of these differences remain a mystery. There is currently no substitute for following antibody and cellular immune responses over time to determine the duration of immunity after infection or vaccination. This is an unsatisfyingly slow solution. A predictive set of cellular and molecular properties in the early immune response would allow for greater success in vaccine development. Read more Theme Lead Image Sam Campos Associate Professor, Immunobiology skcampos@arizona.edu Theme Collaborators Image John Purdy Assistant Professor, Immunobiology jgpurdy@arizona.edu
Activity and Physiological Trackers To Detect And Monitor Pandemic Effects Integration of high-precision laboratory data and computational modeling to inform quantitative microbial risk assessments of pathogen transmission under various conditions within indoor environments. Read more
Immune Vulnerability and SARS- CoV-2 Virus Variants in Older and General Populations There is an urgent need to understand defects of immunity against SARS-CoV-2 in older adults, including its breadth across different antigens of the virus, clonal complexity, functional adequacy, durability, and the ability to guard against virus escape variants. The current pandemic presents a once-in-a-lifetime opportunity to address these needs and fill the gaps in knowledge, with the purpose to protect both adult and older populations from COVID-19. Read more
Predicting the Duration of SARS-CoV-2 The duration of immunity to the SARS-CoV-2 virus varies widely with the specific vaccine or infection, yet the molecular bases of these differences remain a mystery. There is currently no substitute for following antibody and cellular immune responses over time to determine the duration of immunity after infection or vaccination. This is an unsatisfyingly slow solution. A predictive set of cellular and molecular properties in the early immune response would allow for greater success in vaccine development. Read more
